Vitamin D: An Overview of Gene Regulation, Ranging from Metabolism to Genomic Effects.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic and genetic pathways without systematic methodology or original human trial data.
PubMed 37761831 · doi:10.3390/genes14091691
What was done
This narrative review summarizes literature regarding the genetic and metabolic regulation of vitamin D, genomic modulation via vitamin D receptors (VDRs), the role of VDR gene polymorphisms in chronic disease, and rare genetic disorders associated with vitamin D metabolism.
What was found
The abstract reports no quantitative metrics or numerical findings. It qualitatively notes that vitamin D binds VDRs across multiple tissues to regulate hundreds of genomic loci related to cell proliferation, antioxidant defenses, and immunomodulation, and that VDR polymorphisms potentially affect gene expression in various chronic and metabolic conditions.
Why it matters
It provides a consolidated mechanistic overview of how vitamin D functions as a genomic regulator with broad extra-skeletal roles beyond standard bone health and mineral metabolism.
Limits
The paper is a narrative review without systematic search protocols, meta-analytic pooling, or new empirical data. The abstract provides no quantitative data or specific clinical effect sizes.
Cited by
- supports Vitamin D functions biologically as a hormone rather than a true vitamin.
- supports Vitamin D is a prohormone essential for sex and reproductive hormone production, inflammation reduction, and cognition.