Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease.
Level 5 - mechanism / opinion, no new human data
Narrative review of molecular mechanisms and therapeutic targets with no original human empirical data.
PubMed 37779156 · doi:10.1038/s41392-023-01608-z
What was done
This narrative review synthesized literature on the mammalian target of rapamycin (mTOR) signaling pathway, describing the molecular structure of mTORC1 and mTORC2 complexes, upstream regulators, downstream effectors, long noncoding RNA modulation, and therapeutic targeting in cancer and other diseases.
What was found
The review outlines that mTOR phosphorylates multiple targets (including AKT, protein kinase C, IGF-1R, 4E-BP1, S6K, TFEB, SREBPs, Lipin-1, and ULK kinases) to regulate cellular metabolism, translation, lipid and nucleotide synthesis, lysosomal biogenesis, and autophagy. Constitutive activation via genetic alterations is implicated in aging, neurological disorders, and cancer. The abstract reports no empirical numbers or quantitative data.
Why it matters
It provides a consolidated mechanistic overview of mTOR pathway architecture and dysregulation across diseases, highlighting therapeutic strategies and drug resistance challenges for clinical targeting.
Limits
The paper is a narrative review presenting mechanistic descriptions without primary data, systematic search criteria, quantitative meta-analysis, or risk of bias assessments.
Cited by
- supports mTOR forms two distinct cellular complexes: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2).