Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases.
Level 5 - mechanism / opinion, no new human data
Narrative review summarizing mechanistic pathways and disease associations without primary empirical data or systematic search methodology.
PubMed 37781095 · doi:10.3389/fnmol.2023.1247422
What was done
Narrative review summarizing published evidence on the roles of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in neuronal survival, neurogenesis, synaptic function, and the pathogenesis of stress-related cognitive and psychiatric disorders.
What was found
The abstract reports no quantitative data or numerical findings. It qualitatively reports that disruption and downregulation of the BDNF/TrkB signaling system are linked to chronic stress and contribute to cognitive impairment in Alzheimer's disease and mental disorders, suggesting that upregulating BDNF/TrkB signaling may have therapeutic potential.
Why it matters
It provides a conceptual overview linking chronic stress-induced neurotrophin dysfunction to neurodegenerative and psychiatric disease mechanisms.
Limits
The abstract describes a non-systematic narrative review with no primary experimental data, sample sizes, effect sizes, or quantitative synthesis. Details regarding specific experimental models (animal vs. human) and search methodology are not provided.
Cited by
- supports Brain-derived neurotrophic factor (BDNF) stimulates the generation and growth of new brain cells.