Ketone Bodies in Diabetes Mellitus: Friend or Foe?
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic methodology or new human data
PubMed 37892458 · doi:10.3390/nu15204383
What was done
This is a narrative review summarizing existing literature on the physiological and pathological roles of ketone bodies, ketogenic diets, ketonemia, and ketonuria in diabetes mellitus and metabolic disorders.
What was found
The abstract provides a qualitative overview describing the production of ketone bodies under physiological conditions (fasting, exercise, pregnancy, ketogenic diet) and pathological states (diabetic ketoacidosis, alcoholism). It notes the use of ketogenic diets as medical nutrition therapy for obesity and diabetes mellitus. The abstract reports no empirical numbers or quantitative findings.
Why it matters
It distinguishes nutritional ketosis used as a metabolic therapy from acute pathological hyperketonemia in the context of diabetes management.
Limits
As a narrative review, it lacks a systematic search protocol, predefined study selection criteria, risk-of-bias assessment, or quantitative data synthesis. The abstract provides no sample sizes or effect estimates.
Cited by
- supports Ketone bodies can replace glucose as an energy source for the brain, muscles, and most cells in the body, except for erythrocytes.