Sanaya · Current obesity reports 2024 · systematic review of cross-sectional, cohort, and interventional studies · n=23 studies

The Physiological Effects of Weight-Cycling: A Review of Current Evidence.

Cited 29 times in the scientific literature.

Level 3 - non-randomized controlled study

Systematic review of predominantly observational (cross-sectional and cohort) studies and non-RCT interventional designs

PubMed 38172475 · doi:10.1007/s13679-023-00539-8 · record verified 2026-08-30

What was done

A systematic review evaluated the physiological effects of weight-cycling on body weight, BMI, body composition (fat mass and lean body mass), and resting metabolic rate (RMR). The authors included 23 studies (cross-sectional, cohort, and interventional) in generally healthy adults across various age groups, sexes, races, and weight categories (normal weight, overweight, or obesity).

What was found

- Body weight and BMI: 13 of 18 studies found no significant association with weight-cycling. - Fat mass: 15 of 20 studies found no increase. - Lean body mass: 0 of 18 studies found a decrease. - Resting metabolic rate: 12 of 14 studies reported no adverse changes.

Why it matters

This review directly addresses the common belief that yo-yo dieting damages metabolism or increases adiposity, suggesting individuals should not be discouraged from attempting weight loss repeatedly.

Limits

The review combines heterogeneous study designs, including cross-sectional associations that cannot establish causality. The abstract does not report pooled effect sizes, confidence intervals, exact definitions/thresholds used for weight cycling, or risk of bias assessments.

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