Exerkines and cardiometabolic benefits of exercise: from bench to clinic.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic and clinical literature without systematic review methodology.
PubMed 38321233 · doi:10.1038/s44321-024-00027-z
What was done
This narrative review summarizes molecular mechanisms and translational roadmaps for exerkines—humoral factors secreted in response to acute or chronic exercise. The authors examine multi-organ secretomes (muscle, heart, liver, adipose tissue, brain, and gut), gut microbiota contributions, multi-omics biomarker profiling, and exercise-mimetic therapeutic development for cardiometabolic disease management.
What was found
The abstract reports no quantitative values or statistical comparisons. It identifies that hundreds of exerkines (highlighting FGF21, IL-6, and adiponectin) coordinate inter-organ crosstalk, gut microbial factors modulate exercise efficacy, and baseline multi-omics exerkine signatures can predict individual cardiometabolic responses to exercise.
Why it matters
It outlines how exercise-derived biochemical signaling can be leveraged to discover exercise mimetics and develop personalized interventions for diabetes and cardiovascular disease.
Limits
As a narrative review, it presents no original empirical data, quantitative effect estimates, or systematic search methodology. The abstract does not specify the number or types of underlying studies reviewed.
Cited by
- supports Administering an inflammatory marker without physical tissue damage can induce physiological adaptive responses.