Vitamin D and Aging: Central Role of Immunocompetence.
Level 5 - mechanism / opinion, no new human data
Narrative review based on mechanistic reasoning without original empirical human data
PubMed 38337682 · doi:10.3390/nu16030398
What was done
Narrative review describing the molecular and epigenetic mechanisms through which vitamin D3 and its active metabolite 1,25(OH)2D3 interact with the vitamin D receptor to regulate human immune cell gene expression during hematopoiesis and aging.
What was found
The abstract reports no empirical numbers, quantitative data, or effect sizes. It presents a theoretical framework proposing that vitamin D receptor interactions with pioneer factors PU.1 and CEBPA program myeloid lineages and that individual-specific vitamin D responsiveness modulates immunocompetence and aging-related disease risk.
Why it matters
Synthesizes mechanistic biology linking vitamin D epigenetic programming in immune cells to resilience against aging and non-communicable diseases.
Limits
Narrative review design without systematic search criteria or new empirical data. The abstract provides no clinical outcomes, sample size, or experimental validation in human aging cohorts.
Cited by
- supports Vitamin D functions biologically as a hormone rather than a true vitamin.