Focusing on mitochondria in the brain: from biology to therapeutics.
Level 5 - mechanism / opinion, no new human data
Narrative review of biological mechanisms and therapeutic concepts without systematic methodology or primary human data.
PubMed 38632601 · doi:10.1186/s40035-024-00409-w
What was done
This review synthesized literature on mitochondrial biology in brain physiology and pathology, exploring mitochondria-dependent cellular events, the roles of mitochondrial dysfunction in neurological diseases, and potential mitochondrial-targeted therapies.
What was found
The abstract reports no primary experimental or clinical trial data and includes no quantitative statistical findings, other than stating that the brain demands 20% of the resting metabolic rate. It qualitatively notes that mitochondrial defects induce or exacerbate brain pathology and that mitochondrial-targeting therapeutics show potential for brain diseases.
Why it matters
The paper synthesizes how mitochondrial dysfunction contributes to neurological disease phenotypes and highlights emerging strategies targeting mitochondrial mechanisms in the brain.
Limits
As a narrative review, it lacks a systematic search protocol, quality assessment of included studies, or quantitative meta-analytic data. No primary empirical or clinical efficacy numbers are reported in the abstract.
Cited by
- supports The human brain weighs approximately 2 kg but consumes 20% of the body's daily resting energy.