Sex and gender in alcohol use disorder and alcohol-associated liver disease in the United States: A narrative review.
Level 5 - mechanism / opinion, no new human data
Narrative review summarizing literature without systematic search or meta-analytic methods
PubMed 38683562 · doi:10.1097/HEP.0000000000000905
What was done
The authors conducted a narrative review of United States literature to examine the intersection of sex and gender differences in the epidemiology, pathogenesis, and management of alcohol use disorder (AUD) and alcohol-associated liver disease (ALD).
What was found
The abstract reports qualitative trends without providing numerical data. Over the past 20 years, alcohol use, AUD prevalence, and ALD prevalence, severity, and mortality have increased among women in the United States, narrowing historical gender gaps. Sex and gender are described as key factors in AUD development, ALD pathogenesis, and treatment approaches.
Why it matters
This review highlights the rising burden of alcohol-related disease in women and emphasizes the need for tailored prevention, diagnosis, and treatment strategies addressing both biological and sociocultural differences.
Limits
As a narrative review, it lacks a systematic literature search, formal inclusion/exclusion criteria, and risk-of-bias evaluation. No quantitative data, effect estimates, or sample sizes are reported in the abstract. Focus is limited to the United States context.
Cited by
- supports The gender ratio for alcohol use disorder is approximately 60% male to 40% female.