Viral infections and inborn errors of immunity.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic and clinical associations without systematic search methodology.
PubMed 38747352 · doi:10.1097/QCO.0000000000001021
What was done
This focused narrative review examined unusual clinical presentations of viral infections across specific inborn errors of immunity. The authors synthesized clinical and diagnostic observations focusing on hyper immunoglobulin E (IgE) syndromes (specifically DOCK8 deficiency), epidermodysplasia verruciformis, and X-linked agammaglobulinemia in relation to viral susceptibility and pathogenesis.
What was found
The abstract reports qualitative descriptions and provides no quantitative data or numerical outcomes. It highlights that DOCK8 deficiency is associated with aggressive cutaneous disease from herpes simplex and other viruses; epidermodysplasia verruciformis allows rarely detected human papillomavirus (HPV) subtypes to cause malignancy; and patients with X-linked agammaglobulinemia remain at risk for severe and chronic viral infections despite immunoglobulin replacement protecting against bacterial infections.
Why it matters
It highlights that recurrent, severe, or atypical viral presentations are key clinical indicators that should prompt investigation for underlying genetic immunodeficiencies.
Limits
This is a non-systematic narrative review with no defined search protocol, study selection criteria, or sample size metrics. No statistical measures or quantitative outcomes are reported in the abstract.
Cited by
- supports Specific genetic mutations can impair distinct branches of the innate or adaptive immune system, making individuals abnormally vulnerable to specific types or severities of infection.