Integrative effects of resistance training and endurance training on mitochondrial remodeling in skeletal muscle.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic literature without systematic search methodology.
PubMed 38981937 · doi:10.1007/s00421-024-05549-5
What was done
This narrative review synthesized literature on the molecular signaling pathways regulating muscle hypertrophy (mTOR) and mitochondrial remodeling (PGC-1α) in response to isolated resistance training, isolated endurance training, and concurrent training (combined endurance and resistance exercise).
What was found
The abstract reports no numerical data or effect sizes. Qualitatively, the authors report that acute resistance exercise stimulates both hypertrophic and mitochondrial remodeling pathways simultaneously. They state that the resistance component in concurrent training does not suppress endurance-induced mitochondrial remodeling signals and may amplify mitochondrial biogenesis compared to single-mode exercise, proposing that mTOR signaling can promote PGC-1α signaling through as-yet unidentified pathways.
Why it matters
It challenges the classic interference hypothesis by presenting mechanistic evidence that resistance exercise does not necessarily impair mitochondrial adaptations when combined with endurance training.
Limits
As a narrative review, it lacks systematic search criteria, quality appraisal of included studies, and quantitative pooled estimates. No participant counts or study numbers are reported in the abstract. The specific molecular mechanisms linking mTOR activation to PGC-1α upregulation remain uncharacterized, and clinical or performance outcomes are not quantified.
Cited by
- supports High-intensity training and aerobic training have a greater impact on improving mitochondrial health than resistance training.