Psychiatric Manifestations of Neurological Diseases: A Narrative Review.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic methodology or primary human data synthesis
PubMed 39119372 · doi:10.7759/cureus.64152
What was done
This narrative review synthesized the psychiatric manifestations associated with ten neurological conditions: Alzheimer's disease, frontotemporal dementia, Parkinson's disease, multiple sclerosis, stroke, epilepsy, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, and multiple system atrophy. It also evaluated clinical management strategies, ethical issues (such as genetic testing and informed consent), and interdisciplinary care approaches from published literature.
What was found
The abstract provides no quantitative metrics, effect sizes, or prevalence figures. It reports qualitatively that psychiatric symptoms—most notably agitation, depression, anxiety, apathy, hallucinations, impulsivity, and aggression—are common across the evaluated neurological conditions and substantially affect patient well-being and outcomes.
Why it matters
It provides a broad overview connecting neuropsychiatric symptoms across disparate central nervous system disorders, highlighting the need for interdisciplinary care and attention to ethical challenges like consent and end-of-life planning.
Limits
The review relies on a narrative rather than systematic design, with no documented search criteria, study selection parameters, or risk-of-bias assessment. No quantitative rates or comparative effectiveness data for interventions were reported in the abstract.
Cited by
- supports Apathy commonly occurs across multiple neurological disorders, including stroke, Alzheimer's disease, Parkinson's disease, and multiple sclerosis.