Magnesium (Mg 2+ ): Essential Mineral for Neuronal Health: From Cellular Biochemistry to Cognitive Health and Behavior Regulation.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing preclinical mechanisms and clinical literature without systematic review methodology
PubMed 39253923 · doi:10.2174/0113816128321466240816075041
What was done
This narrative review synthesized literature on the cellular biochemistry, neuroprotective mechanisms, and clinical relevance of magnesium. The authors examined its role as an enzymatic cofactor, its modulation of ion channels and synaptic plasticity, its relationship to neuropsychiatric disorders (such as depression, anxiety, and cognitive decline), and the therapeutic potential of bioavailable magnesium compounds including Magnesium-L-Threonate and Magnesium-Acetyl-Taurate.
What was found
The abstract reports no primary numerical data, sample sizes, or effect estimates. It qualitatively describes that magnesium serves as a cofactor in over 300 enzymatic reactions, mitigates oxidative stress, inflammation, and excitotoxicity, and notes that supplementation has shown promising results in supporting synaptic density, memory function, and mental health symptoms.
Why it matters
Synthesizing the neurobiological pathways of magnesium provides a mechanistic foundation for developing and testing specific bioavailable magnesium formulations in targeted psychiatric and neurodegenerative clinical trials.
Limits
The abstract contains no quantitative metrics, dosage data, or systematic search protocols. As a narrative review, it carries inherent selection bias and synthesizes preclinical and clinical evidence without assessing the risk of bias or methodological quality of cited studies.
Cited by
- supports ATP synthesis in human cells cannot occur without magnesium.