Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.
Level 1 - systematic review of randomized trials
Systematic review and meta-analysis of randomized controlled trials
PubMed 39404918 · doi:10.1007/s10072-024-07794-0
What was done
A systematic review and dose-response meta-analysis of randomized controlled trials evaluated the effects of dietary supplements for migraine prophylaxis compared to control/placebo groups. Key outcomes assessed were migraine attack frequency, duration in hours, severity, and monthly migraine days. Certainty of evidence was evaluated using the GRADE tool.
What was found
Twenty-two trials were analyzed. Compared with control groups: - Magnesium reduced attack frequency (mean difference [MD] = -2.51), severity (MD = -0.88), and monthly migraine days (MD = -1.66). - CoQ10 reduced frequency (MD = -1.73), severity (MD = -1.35), and duration (MD = -1.72 hours). - Riboflavin reduced attack frequency (MD = -1.34). - Alpha-lipoic acid reduced attack frequency (MD = -1.24) and severity (MD = -0.38). - Probiotics reduced frequency (MD = -1.16), severity (MD = -1.07), and monthly migraine days (MD = -3.02). - Vitamin D reduced frequency (MD = -1.69) and monthly migraine days (MD = -2.41). - Omega-3 supplementation yielded no statistically significant reduction in any outcome. Confidence intervals and specific dose-response thresholds were omitted in the abstract.
Why it matters
This meta-analysis provides comparative effect sizes for multiple common over-the-counter supplements in migraine prevention, identifying several options with measurable reductions in attack frequency or days while showing no benefit for omega-3.
Limits
Total participant count, specific dosages, follow-up durations, and safety data were not reported in the abstract. Distributing 22 trials across seven distinct supplement categories implies small sample sizes and few studies per individual supplement. Confidence intervals and GRADE rating details were not provided in the abstract.
Cited by
- supports Magnesium supplementation, alongside B vitamins and CoQ10, is effective in alleviating migraine symptoms and associated tinnitus or dizziness exacerbations.