Managing the neuroinflammatory pain of endometriosis in light of chronic pelvic pain.
Level 5 - mechanism / opinion, no new human data
Narrative review and expert opinion without systematic search methods or primary empirical data.
PubMed 39540855 · doi:10.1080/14656566.2024.2425727
What was done
This is a narrative review describing the pathophysiology of endometriosis, focusing on neuroinflammatory processes, peripheral and central sensitization, and chronic pelvic pain. It outlines treatment strategies including first-line hormonal therapies, add-back therapy, analgesics, anticonvulsants, and psychological approaches based on existing literature.
What was found
The abstract reports that endometriosis affects 5% to 10% of reproductive-age women. No original empirical data, quantitative findings, or statistical effect estimates are reported.
Why it matters
It conceptualizes endometriosis as a systemic neuroinflammatory condition with neuropathic and sensitization components, arguing for multimodal and individualized treatment rather than standard hormonal suppression alone.
Limits
This is an unsystematic narrative review with no primary data, quantitative synthesis, or explicit methodology for study selection.
Cited by
- supports Endometriosis-associated chronic pelvic pain involves central sensitization triggered by nerve fibers growing into endometriotic lesions.