Telomerase-Mediated Anti-Ageing Interventions.
Level 5 - mechanism / opinion, no new human data
Narrative review of biological mechanisms with no original human clinical data.
PubMed 39693017 · doi:10.1007/978-3-031-66768-8_1
What was done
This narrative review summarizes mechanisms of chromosome end-replication, telomere attrition, and cellular senescence, and reviews potential anti-ageing interventions aimed at increasing telomerase expression or enzymatic activity along with their risks and benefits.
What was found
The abstract provides no empirical numbers or quantitative data. It outlines the biological rationale that progressive telomere shortening induces DNA damage responses and senescence in somatic tissues, and describes telomerase activation as a potential approach to counteract cellular ageing.
Why it matters
Telomerase modulation is a key theoretical avenue in geroscience for maintaining cellular replicative capacity. This review provides an overview of the mechanistic rationale and safety considerations for such approaches.
Limits
The work is a narrative review chapter presenting no new experimental data or systematic evidence synthesis. No human clinical outcomes, quantitative measures, or specific study sample sizes are reported in the abstract.
Cited by
- supports Telomeres shorten with each cell division until they reach a critically short length, at which point the cell can no longer divide properly.