Skin Sceneries of Thyroid Disorders and Impact of Thyroid on Different Skin Diseases: A Scoping Review Focused on Pediatric Patients.
Level 5 - mechanism / opinion, no new human data
Scoping review summarizing literature and biological mechanisms without quantitative meta-analysis
PubMed 39767917 · doi:10.3390/children11121488
What was done
A scoping review was conducted to synthesize existing literature on the relationship between thyroid disorders, biological signaling in the "thyroid-skin axis", and dermatological presentations specifically in pediatric patients. The abstract does not provide specific search database details or inclusion counts.
What was found
The abstract provides no numerical data, effect sizes, or study counts. It qualitatively reports that common skin conditions associated with pediatric thyroid dysfunction include chronic urticaria, vitiligo, and alopecia, driven by thyroid hormone influence on keratinocyte proliferation, hair growth, and epidermal differentiation.
Why it matters
Recognizing that chronic skin conditions can precede overt symptoms of thyroid disease may encourage clinicians to perform earlier endocrine screening in affected children.
Limits
The abstract reports no quantitative results, sample sizes, or screening performance metrics. There are currently no standardized management guidelines established from this synthesis, and findings rely on variable underlying observational and mechanistic studies.
Cited by
- context Low thyroid function impairs keratinocyte turnover, leading to cystic acne, keratosis pilaris, rough skin, and ingrown toenails.