Whipple · Pain 1985 · Within-subject controlled laboratory experiment · n=20

Elevation of pain threshold by vaginal stimulation in women.

Cited 138 times in the scientific literature.

Level 3 - non-randomized controlled study

Small non-randomized within-subject controlled laboratory experiment

PubMed 4000685 · doi:10.1016/0304-3959(85)90164-2 · record verified 2026-08-29

What was done

Two laboratory studies of 10 women each evaluated the effect of vaginal self-stimulation (via a pressure transducer assembly producing sensations of pressure, pleasure, or orgasm) on sensory thresholds. Investigators measured detection and tolerance thresholds for painful mechanical finger compression alongside detection thresholds for innocuous tactile stimulation, comparing findings against control conditions including distraction.

What was found

Vaginal self-stimulation significantly elevated pain thresholds without altering tactile detection thresholds: - In Study 1, pleasurable stimulation (n=6) increased pain tolerance thresholds by 36.8% and pain detection thresholds by 53.0%. - In Study 2, stimulation perceived as pressure increased pain tolerance thresholds by 40.3% and pain detection thresholds by 47.4%. - In Study 2, stimulation producing orgasm increased pain tolerance thresholds by 74.6% and pain detection thresholds by 106.7%. - Various distraction controls did not significantly alter pain or tactile thresholds.

Why it matters

This study provides early laboratory evidence in humans that vaginal stimulation selectively reduces pain sensitivity rather than general tactile perception, an effect not explained by distraction.

Limits

The sample size was very small (10 women per study), the abstract does not report randomization or blinding procedures, and outcomes were restricted to acute mechanical finger compression in an artificial laboratory setting.

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