Bjørklund · Current medicinal chemistry 2025 · Narrative review · n=?

Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.

Cited 9 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review without systematic search or meta-analysis

PubMed 40045862 · doi:10.2174/0109298673348175250214054101 · record verified 2026-08-29

What was done

This is a narrative review summarizing the physiological roles of major minerals (calcium, potassium, sodium, sulfur, magnesium) and trace elements (iron, zinc, selenium, copper, manganese, silicon) in skin health, aging, and dermatological conditions (such as eczema, psoriasis, acne, lichen planus, vitiligo, alopecia areata, and skin cancer). It also addresses oral and topical routes of administration and potential toxicities from certain trace elements used in cosmetics.

What was found

The abstract provides no numerical data, effect sizes, or study counts. It qualitatively notes that mineral and trace element deficiencies may impair skin appearance and contribute to disorders, and that adequate saturation via diet, supplements, or topical products plays a positive role in skin health maintenance and disease management.

Why it matters

This review outlines the therapeutic and cosmetic relevance of mineral repletion across multiple dermatological conditions while highlighting the risk of toxic trace elements in topical formulations.

Limits

As a narrative review, it does not use systematic search methods, study quality appraisals, or quantitative synthesis. The abstract lacks specific clinical outcomes, effective dosages, comparative efficacy between oral and topical delivery routes, and safety thresholds for toxic elements.

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