Mitochondria in focus: From structure and function to their role in human diseases. A review.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analysis
PubMed 40237329 · doi:10.5507/bp.2025.009
What was done
This is a narrative review summarizing literature on mitochondrial structure and multifaceted biological roles, including oxidative phosphorylation, apoptosis, calcium regulation, reactive oxygen species signaling, inter-mitochondrial communication, their contribution to disease and aging, and the restorative role of regular exercise.
What was found
The abstract reports no quantitative data or specific numerical metrics. It qualitatively summarizes that mitochondrial dysfunction contributes to age-related conditions and human diseases, whereas regular exercise enhances mitochondrial volume, density, and functionality.
Why it matters
This review provides an overview of mitochondrial physiology and pathology, emphasizing the value of targeting mitochondrial health through lifestyle factors like exercise to support longevity.
Limits
This is a non-systematic narrative review with no original clinical or experimental data. The abstract provides no quantitative effect sizes, details on literature search methods, or specific study populations.
Cited by
- partial Mitochondria are the mandatory endpoint of all aerobic exercise and the site of ATP generation when oxygen is used as a byproduct to make fuel.