The Pivotal Role of Thiamine Supplementation in Counteracting Cardiometabolic Dysfunctions Associated with Thiamine Deficiency.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanisms and clinical literature without systematic review or meta-analytic methods
PubMed 40243711 · doi:10.3390/ijms26073090
What was done
This narrative review examined the biochemical role of thiamine in carbohydrate metabolism and the physiological consequences of thiamine deficiency and accumulation. The authors reviewed literature on how deficiency contributes to metabolic dysfunction, cardiovascular disease, heart failure, atherosclerosis, and cancer therapy-induced cardiotoxicity, as well as the effects of thiamine supplementation on glycemic control, lipid profiles, oxidative stress, and inflammation.
What was found
No quantitative findings or effect sizes were reported in the abstract. The authors reported that preclinical literature consistently shows thiamine supplementation counteracts oxidative stress and inflammation while improving glycemic and lipemic profiles, but existing human clinical trial findings remain contradictory and inconsistent.
Why it matters
This review synthesizes the mechanistic basis for thiamine's role in cardiovascular and metabolic health while identifying that current clinical trial evidence is too limited to support definitive therapeutic conclusions.
Limits
The abstract describes a narrative review with no systematic search criteria, meta-analysis, or study count reported. Human clinical evidence discussed is constrained by small sample sizes, insufficient follow-up durations, and conflicting results.
Cited by
- supports Alcohol consumption can impair thiamine absorption from the digestive tract and inhibit the enzyme that converts thiamine into its active form.