The molecular landscape of cellular metal ion biology.
Level 5 - mechanism / opinion, no new human data
Bench research using a yeast model organism
PubMed 40516524 · doi:10.1016/j.cels.2025.101319
What was done
The authors systematically quantified yeast cell growth and mapped metallomic, proteomic, and genetic responses across concentration gradients of all growth-essential metal ions.
What was found
Around half of the yeast proteome and most signaling pathways, including target of rapamycin (TOR), responded to metal availability gradients. Responses to individual metals were distinct but showed common features such as concentration interdependencies and metal homeostasis. Metalloenzymes occupied central nodes in metabolic networks, and metal-related functions were indicated for understudied proteins. The abstract does not report specific numerical values, effect sizes, or test statistics.
Why it matters
This resource maps how availability of essential metal ions globally remodels the eukaryotic proteome, signaling networks, and metabolic organization.
Limits
Findings are derived entirely from an in vitro yeast model, limiting direct translation to human physiology. The abstract does not report specific numbers of replicates, metal concentrations tested, or statistical effect sizes.
Cited by
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