Translational Insights Into Pericyte-Mediated Regulation of Cerebral Blood Flow: Implications for Ischemic Stroke.
Level 5 - mechanism / opinion, no new human data
Narrative review of biological mechanisms and preclinical strategies without new clinical data.
PubMed 40557479 · doi:10.1161/STROKEAHA.125.052018
What was done
This narrative review synthesized the mechanistic roles of pericytes in regulating capillary tone and regional hemodynamics, evaluating potential pericyte-targeted strategies for microvascular reperfusion in ischemic stroke based on the literature.
What was found
The abstract reports no numerical data. It notes qualitatively that pericytes critically control post-ischemic microcirculatory blood flow, existing targeted interventions remain limited, and current strategies face issues such as adverse effects, structural instability, suboptimal efficacy, and translational hurdles.
Why it matters
Addressing microvascular tone via pericytes offers a potential therapeutic avenue to overcome no-reflow and improve tissue reperfusion in ischemic stroke beyond macroscopic recanalization.
Limits
As a narrative review, it lacks a systematic search protocol, meta-analytic pooling, and primary clinical outcome data. Specific quantitative effect sizes and human trial metrics are not reported in the abstract.
Cited by
- supports Brain pericytes express contractile proteins that allow them to constrict and dilate cerebral blood vessels.