Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation.
Level 2 - randomized trial
Systematic review combining animal and human studies rather than exclusively randomized clinical trials
PubMed 40563371 · doi:10.3390/antiox14060740
What was done
Systematic review and meta-analysis of 28 articles published between 2000 and 2025, including both animal and human studies. The authors evaluated the effects of dietary and supplemental magnesium on inflammatory and oxidative stress biomarkers, specifically nitric oxide (NO), total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), and C-reactive protein (CRP).
What was found
Magnesium supplementation produced a statistically significant reduction in CRP levels, indicating an anti-inflammatory effect. No conclusive impact was found across the evaluated oxidative stress biomarkers (NO, TAC, MDA, GSH). The abstract reports no numerical effect sizes, point estimates, confidence intervals, or p-values.
Why it matters
The review supports an anti-inflammatory role for magnesium via CRP reduction while demonstrating that evidence for direct antioxidant effects remains inconclusive.
Limits
The analysis combines animal and human studies rather than restricting to randomized clinical trials. The abstract does not report study-level sample sizes, magnesium doses, forms, intervention durations, or numerical effect sizes.
Cited by
- supports Magnesium is involved in approximately 300 different biochemical functions in the human body.