[Research progress on molecular mechanism of resistance training-induced skeletal muscle hypertrophy: the crucial role of mTOR signaling].
Level 5 - mechanism / opinion, no new human data
Narrative literature review synthesizing mechanistic and pathway research
PubMed 40566722 · doi:10.13294/j.aps.2025.0048
What was done
This paper reviewed human and animal literature exploring the molecular mechanisms of resistance training-induced skeletal muscle hypertrophy, with a specific focus on the regulatory roles of mammalian target of rapamycin (mTOR) and mTOR complex 1 (mTORC1) signaling pathways, ribosome biogenesis, translation capacity, and satellite cell activation.
What was found
The abstract reports no quantitative values or effect estimates. It outlines qualitative mechanistic concepts: mTORC1 acts as a primary regulator of hypertrophic adaptation to resistance training; human trials predominantly correlate mTOR signaling with muscle protein synthesis, whereas animal research elucidates upstream and downstream effectors of mTORC1, including its role in satellite cell activation and myofiber fusion.
Why it matters
Understanding the molecular cascade of mTOR signaling clarifies how mechanical loading translates into muscle remodeling, which informs interventions targeting sarcopenia, clinical rehabilitation, and athletic conditioning.
Limits
As a narrative review, it lacks a systematic literature search, formal inclusion/exclusion criteria, and risk of bias assessment. The abstract reports no primary experimental data or quantitative metrics. Discrepancies between human correlational studies and animal mechanistic models limit direct clinical translation.
Cited by
- supports mTOR activation is the primary mechanistic pathway responsible for skeletal muscle hypertrophy from resistance training.