Leftward asymmetry of the planum temporale and its association with language.
Level 5 - mechanism / opinion, no new human data
Narrative mini-review synthesizing existing literature without systematic methodology
PubMed 40613889 · doi:10.1007/s00429-025-02980-y
What was done
This mini-review synthesized evidence from post-mortem histological studies and in-vivo neuroimaging literature evaluating both macrostructural (volume, cortical thickness, surface area) and microstructural (neurite density, columnar organization) left-right asymmetries of the planum temporale in relation to functional language lateralization.
What was found
The abstract reports no quantitative values, sample sizes, or effect sizes. It reports that previous studies linking macrostructural asymmetries to language processing yielded ambiguous and contradictory results, whereas recent investigations indicate that microstructural asymmetries exhibit stronger associations with functional hemispheric language lateralization.
Why it matters
It highlights that understanding structure-function associations in language processing requires incorporating microstructural metrics rather than relying solely on coarse macrostructural brain imaging measures.
Limits
This is a narrative mini-review presenting mechanism-based arguments and literature synthesis without systematic search criteria, meta-analytic pooling, or quantitative data reported in the abstract.
Cited by
- supports Language centers of the human brain are localized in the left hemisphere.