Creatine monohydrate supplementation for older adults and clinical populations.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analysis
PubMed 40673730 · doi:10.1080/15502783.2025.2534130
What was done
Authors conducted a narrative review summarizing research on the efficacy and safety of creatine monohydrate supplementation in older adults and clinical populations across musculoskeletal, metabolic, and cognitive domains.
What was found
The abstract reports no numerical values, sample sizes, or effect estimates. It qualitatively concludes that creatine monohydrate, primarily in combination with exercise training, is safe and has beneficial effects on whole-body lean mass, regional muscle size, muscle strength, bone area and thickness, functional ability, glucose kinetics, cognition, and memory.
Why it matters
This paper consolidates evidence supporting creatine supplementation as an adjunct therapy for counteracting age-related physical and cognitive decline, including sarcopenia, osteoporosis, and frailty.
Limits
As a narrative review, it lacks systematic search criteria, quality appraisal, and meta-analytic pooling. The abstract does not provide specific quantitative findings, dosing regimens, or intervention durations.
Cited by
- supports High doses of creatine can be administered to frail, older individuals with essentially no side effects.
- supports Intramuscular creatine levels in the lower limbs decline with advancing age.