Ketone body, as an emerging modulator of metabolic reprogramming and epigenetics in breast cancer.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic concepts and preclinical literature with no new clinical data
PubMed 40809180 · doi:10.22038/ijbms.2025.84064.18185
What was done
This paper reviewed literature on metabolic characteristics of breast tumors, focusing on ketone body metabolism, the role of ketogenic diets in glucose restriction, and the interactions between ketone bodies and epigenetic regulation in tumor cells.
What was found
The abstract reports no numerical findings or quantitative metrics. It notes conflicting qualitative literature: while ketogenic diets are explored to restrict glucose availability to tumors, other studies suggest that cancer cells utilizing ketone bodies as an energy source may exhibit increased invasiveness and altered epigenetic patterns.
Why it matters
It emphasizes the metabolic plasticity of breast cancer cells and cautions that ketogenic strategies may have complex or counterproductive effects on tumor invasiveness via epigenetic reprogramming.
Limits
This is a narrative review with no original experimental or clinical data. The abstract provides no quantitative effect sizes, patient data, or systematic methodology to resolve contradictory literature.
Cited by
- context The addition of ketones to cancer cells decreases their proliferation via a ketone-induced reduction in the glycolytic enzyme hexokinase.