Diamine oxidase deficiency implications for health, current management, and future directions in the treatment of histamine intolerance: A review.
Level 5 - mechanism / opinion, no new human data
Narrative review of biological mechanisms, clinical studies, and therapeutic strategies without systematic review methodology
PubMed 40865824 · doi:10.1016/j.ijbiomac.2025.147130
What was done
This narrative review summarizes the biological role of diamine oxidase (DAO) in histamine metabolism and its link to histamine intolerance (HIT). The authors examine genetic and dietary influences on DAO activity, analyze clinical trials evaluating exogenous DAO supplementation, compare various DAO-rich supplement sources, and discuss diagnostic and regulatory limitations in clinical practice.
What was found
The abstract provides no quantitative data or specific numerical trial results. It reports qualitatively that DAO deficiency leads to multi-system manifestations including migraines, gastrointestinal issues, and allergy-like symptoms, and notes that DAO supplementation shows therapeutic potential for mitigating HIT symptoms despite variability in supplement sources.
Why it matters
It outlines the current state of DAO-targeted interventions and underscores the critical need for standardized diagnostic criteria and regulatory frameworks for DAO supplements.
Limits
As a narrative review, it lacks systematic search methodology, formal study selection criteria, and quantitative synthesis or meta-analysis. The abstract does not specify the number or sample sizes of the underlying clinical trials reviewed.
Cited by
- supports Diamine oxidase (DAO) is an enzyme that helps counteract and break down histamine accumulation in the body.