Mini-review on insulin resistance assessment: Advances in surrogate indices and clinical applications.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analytic methodology
PubMed 40933937 · doi:10.12998/wjcc.v13.i29.108380
What was done
Narrative mini-review summarizing the clinical utility, strengths, and limitations of surrogate indices for assessing insulin resistance (including HOMA-IR, QUICKI, Matsuda index, and triglyceride-glucose [TyG] index) compared to the gold-standard hyperinsulinemic-euglycemic clamp.
What was found
The abstract provides no numerical data, diagnostic accuracy statistics, or effect estimates. It qualitatively reports that surrogate indices derived from fasting and post-load glucose and insulin measurements facilitate risk stratification, but noted their performance and applicability vary depending on ethnic background, disease status, and clinical setting.
Why it matters
Provides a high-level overview of accessible, non-invasive alternatives to complex clamp techniques for metabolic risk assessment in routine clinical care.
Limits
As a narrative review, it presents no original empirical data, systematic search criteria, or pooled meta-analytic performance metrics. Specific optimal cut-offs and comparative diagnostic parameters are not quantified in the abstract.
Cited by
- supports The euglycemic hyperinsulinemic clamp is the gold standard for measuring insulin resistance.