The impact of high-sugar diets on central nervous system disorders: mechanisms, pathogenesis, and dietary implication.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic literature without systematic quantitative synthesis
PubMed 40963410 · doi:10.1080/07853890.2025.2561789
What was done
The authors conducted a literature review by searching databases including PubMed, Medline, and PubMed Central (PMC) to examine the mechanisms and pathogenesis linking high-sugar diets (particularly high glucose and fructose) to central nervous system (CNS) disorders, including Alzheimer's disease, Parkinson's disease, and stroke.
What was found
The abstract outlines qualitative mechanistic links rather than quantitative data: excessive sugar intake contributes to insulin resistance, advanced glycation end products (AGEs), oxidative stress, systemic and neuroinflammation, blood-brain barrier dysfunction, and altered neurotransmission. The abstract provides no quantitative effect sizes, odds ratios, or sample numbers.
Why it matters
It consolidates existing evidence connecting metabolic dysfunction driven by high-sugar consumption to neurological disease progression, highlighting the potential for dietary interventions targeting brain health.
Limits
The abstract reflects a narrative review without formal systematic review methodology (e.g., PRISMA adherence, standardized quality appraisal, or meta-analysis). It reports no quantitative data or human trial outcomes, limiting the ability to establish causal thresholds or effect sizes in humans.
Cited by
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