Bisphenol A and human fertility: a systematic review.
Level 3 - non-randomized controlled study
Systematic review of observational and exposure studies (by design analogy)
PubMed 40986713 · doi:10.5935/1518-0557.20250029
What was done
A systematic review examining literature on the correlation between bisphenol A (BPA) exposure and human fertility in men and women of reproductive age. The abstract does not specify search databases, inclusion criteria, or the number of included studies.
What was found
The abstract reports no numerical values, effect sizes, or confidence intervals. It qualitatively reports that BPA exposure was linked to altered ovarian reserve parameters, hormonal disruptions, impaired folliculogenesis, lower estradiol concentrations, worsened ovarian response in assisted reproduction, reduced fertilization rates, higher implantation failure, fetal malformations, increased spontaneous abortions, and premature births in women. In men, BPA was linked to decreased sperm production, testicular dysgenesis syndrome, and cryptorchidism.
Why it matters
It summarizes potential multi-pathway reproductive hazards of BPA exposure across natural conception, pregnancy, and assisted reproduction in both sexes.
Limits
The abstract reports no quantitative estimates or meta-analyses, nor does it state the number or designs of included studies. Findings based on observational exposure literature remain subject to confounding, exposure measurement error, and unmeasured environmental co-exposures.
Cited by
- supports BPA, phthalates, PFAS, and pesticides/herbicides have published human outcome data linking exposure to adverse fertility outcomes including eggs retrieved, time to conception, and sperm quality.