Photobiomodulation by infrared radiation on hallmarks of cancer.
Level 5 - mechanism / opinion, no new human data
Narrative review of preclinical (in vitro and in vivo) experimental studies
PubMed 40996549 · doi:10.1007/s10103-025-04625-2
What was done
The authors reviewed literature retrieved from MEDLINE/PubMed to examine the effects of photobiomodulation (PBM) induced by infrared A radiation across the hallmarks of cancer in in vitro and in vivo preclinical models.
What was found
The abstract reports no quantitative data or specific directional results. It notes that published research on infrared A photobiomodulation has evaluated only 4 of the 14 cancer hallmarks (sustaining proliferative signaling, evading growth suppressors, genomic instability and mutation, and resisting cell death), leaving 10 hallmarks uninvestigated.
Why it matters
Identifying that ten major hallmarks of cancer remain unstudied under infrared photobiomodulation clarifies the substantial gaps in fundamental mechanistic understanding before considering clinical oncologic translation.
Limits
The review is limited to preclinical in vitro and animal models with no direct clinical human data. The abstract provides no specific study count, search dates, screening criteria, methodological quality assessment, or direction of biological effect for the four examined hallmarks.
Cited by
- supports Long-wavelength light, including red, near-infrared, and infrared, is non-ionizing radiation.