The Gut Microbiota Axis in Social Jetlag: A Novel Framework for Metabolic Dysfunction and Chronotherapeutic Innovation.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic, preclinical, and emerging clinical concepts without systematic review methodology.
PubMed 41011021 · doi:10.3390/medicina61091630
What was done
This narrative review synthesized preclinical mechanistic literature and emerging clinical evidence examining how social jetlag disrupts the microbiota-gut-metabolic axis and evaluated chronotherapeutic interventions such as time-restricted eating, melatonin, probiotics, and fecal microbiota transplantation.
What was found
The abstract reports purely qualitative conclusions with no numbers or statistical values. It states that social jetlag disrupts microbial diurnal rhythms, reduces short-chain fatty acid production, impairs intestinal barrier integrity, and promotes systemic inflammation and insulin resistance, while circadian-aligned interventions show potential to restore metabolic homeostasis.
Why it matters
It outlines a biological framework connecting lifestyle-driven circadian disruption to metabolic disease through the microbiome, highlighting potential chronotherapeutic targets.
Limits
This is a narrative review with no systematic search protocol, risk-of-bias evaluation, or meta-analysis. The underlying evidence relies heavily on mechanistic and preclinical findings, and the abstract provides no human sample sizes or quantitative effect estimates.
Cited by
- supports Maintaining healthy sleep patterns and avoiding erratic sleep-wake behavior affects the microbiome and host regulation of weight and glucose metabolism.