The acute effect of glyphosate on heart mitochondria does not impair the bioenergetics.
Level 5 - mechanism / opinion, no new human data
Bench research / in vitro animal tissue model (isolated swine heart mitochondria)
PubMed 41054226 · doi:10.1080/00498254.2025.2568631
What was done
This study evaluated the acute in vitro toxicity of glyphosate on mitochondrial function using isolated swine heart mitochondria. Outcomes measured included mitochondrial respiration, mitochondrial swelling, and F1FO-ATPase activity.
What was found
Glyphosate showed no statistically significant effect on mitochondrial respiration, mitochondrial swelling, or F1FO-ATPase activity under the experimental conditions tested. The abstract does not report any quantitative values, concentrations tested, or effect sizes.
Why it matters
These findings suggest that pure glyphosate alone does not cause direct acute cardiotoxicity via mitochondrial bioenergetic impairment in this model, pointing to formulation adjuvants or interactions as alternative drivers of cardiotoxicity observed with commercial herbicides.
Limits
This is an in vitro bench study using isolated swine organelles, precluding direct extrapolation to human whole-organism physiology or in vivo toxicity. The abstract provides no sample sizes (n), tested dose/concentration ranges, exposure durations, or numerical data. Commercial formulations and adjuvants were not directly tested.
Cited by
- context Glyphosate functions as a mitochondrial toxin.