The promising role of muse cells in regenerative medicine: Mechanisms, applications, and future directions.
Level 5 - mechanism / opinion, no new human data
Narrative review of biological mechanisms and preclinical potential with no original human trial data
PubMed 41106719 · doi:10.1016/j.lfs.2025.124024
What was done
This narrative review summarizes the biological characteristics, molecular mechanisms, and therapeutic potential of multilineage-differentiating stress-enduring (Muse) cells across several targets, including stroke, myocardial infarction, osteoarthritis, and radiation-induced intestinal injury.
What was found
The abstract reports no quantitative results or specific effect sizes. It qualitatively describes Muse cells as naturally occurring, stress-resistant, self-renewing stem cells that achieve multilineage tissue repair without tumor formation or significant immune rejection.
Why it matters
Muse cells represent a potential avenue in regenerative medicine, theoretically offering multilineage differentiation capacity without common safety limitations like teratoma formation.
Limits
This is a narrative review without systematic search criteria or original empirical data. The abstract provides no quantitative safety or efficacy endpoints.
Cited by
- supports Multilineage-differentiating stress-enduring (Muse) cells have low immunogenicity and low tumorigenicity compared to other stem cells.