Ghai · Complementary medicine research 2025 · systematic review and meta-analysis · n=12 studies (1,176 participants)

Yoga Nidra and Pain: A between-, within-Group Meta-Analysis and Dose Response Meta-Regression.

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Level 1 - systematic review of randomized trials

Systematic review and meta-analysis of randomized and non-randomized quantitative studies

PubMed 41187098 · doi:10.1159/000549416 · record verified 2026-08-26

What was done

Authors conducted a systematic review and random-effects meta-analysis across seven databases and one trial registry to assess the effects of Yoga Nidra (YGN) on pain outcomes. Eligible quantitative designs included both randomized controlled trials and non-randomized studies. Methodological quality was evaluated using the Cochrane Risk of Bias tool for randomized trials and the modified Downs and Black checklist for non-randomized studies. Meta-regression and subgroup analyses were performed to examine dose-response relationships.

What was found

Twelve studies comprising 1,176 participants met inclusion criteria. - Comparison with passive controls: YGN significantly reduced pain (Hedges' g: -2.05, p = 0.01). - Comparison with active controls: No statistically significant difference in pain reduction was observed (Hedges' g: -0.31, p = 0.53). - Within-group change: Significant pain reduction was observed following YGN (Hedges' g: -2.01, p < 0.001). - Dose-response: Subgroup analyses (single vs. multiple sessions) and meta-regressions revealed no significant dose-response relationship across intervention durations.

Why it matters

Yoga Nidra demonstrates potential as a non-invasive mind-body approach for pain reduction compared to no treatment, although it does not appear superior to other active interventions.

Limits

The primary limitation is the low overall methodological quality of the included studies, which the authors note may have resulted in inflated effect estimates. The review combined randomized and non-randomized studies, and the abstract does not report specific pain etiologies, long-term durability, or adverse events.

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