Klotho in aging and diseases: molecular features, expressions, and functional implications.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic and biological concepts without original human data or systematic review methodology
PubMed 41296273 · doi:10.1007/s11010-025-05445-2
What was done
This is a narrative review examining the molecular characteristics, expression patterns, and physiological functions of the Klotho protein. The authors synthesize existing literature regarding how Klotho interacts with metabolic pathways to maintain systemic homeostasis and mitigate age-associated organ decline.
What was found
The abstract reports no quantitative data or specific statistical values. It describes qualitative observations from the literature: genetic deletion of Klotho precipitates accelerated multi-organ aging phenotypes, endogenous Klotho levels decline in aged populations, and Klotho expression provides protective effects across multiple tissues.
Why it matters
It provides a consolidated conceptual overview of Klotho biology, framing Klotho replacement or upregulation as a potential therapeutic strategy for chronic, age-associated diseases.
Limits
The paper is a narrative overview providing no primary clinical or experimental data, and the abstract provides no numerical outcomes, search parameters, or study selection criteria.
Cited by
- supports The protein Klotho has been shown to produce beneficial effects across multiple organ systems in animal models.