Zhang · Frontiers in physiology 2025 · systematic review and meta-analysis of randomized controlled trials · n=666

Comparative effects of high-intensity and sprint interval training on cardiorespiratory fitness and body composition: a systematic review with meta-analysis.

Cited 3 times in the scientific literature.

Level 1 - systematic review of randomized trials

Systematic review and meta-analysis of randomized controlled trials

PubMed 41306569 · doi:10.3389/fphys.2025.1668326 · record verified 2026-08-30

What was done

A systematic review and meta-analysis (PROSPERO CRD420251016362) synthesized 9 randomized controlled trials with 666 total participants to evaluate the effects of high-intensity interval training (HIIT) and sprint interval training (SIT). Primary outcomes were changes in VO2 max/VO2 peak and body fat percentage. Analyses used standardized mean differences (SMD) or weighted mean differences (WMD), stratified by health and training status (healthy/trained vs. overweight/obese).

What was found

Compared to controls, both interval training modalities combined significantly improved cardiorespiratory fitness (SMD = 1.54; 95% CI: 0.89 to 2.18; p < 0.00001) and reduced body fat mass (WMD = -3.45%; 95% CI: -5.04 to -1.87; p < 0.0001). In subgroup analyses, HIIT was more effective than SIT for cardiorespiratory fitness in overweight/obese individuals (SMD = -0.97; p = 0.0004), whereas SIT was more effective for fat loss in healthy or trained individuals (WMD = 5.85; p < 0.00001).

Why it matters

This review suggests the relative benefits of HIIT versus SIT depend on baseline fitness and body composition, supporting targeted exercise prescription based on an individual's starting health status.

Limits

The analysis included only 9 trials with 666 total participants across all subgroups. The abstract does not report study-level intervention lengths, specific exercise protocols, compliance, dietary control, or adverse events.

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