From Elixirs to Geroscience: A Historical and Molecular Perspective on Anti-Aging Medicine.
Level 5 - mechanism / opinion, no new human data
Narrative review and historical synthesis without primary data or systematic search methodology
PubMed 41471752 · doi:10.3390/molecules30244728
What was done
This narrative and historical review traces the conceptual evolution of longevity medicine from ancient practices to modern molecular geroscience, outlining historical milestones, mechanistic pathways, and candidate interventions across model organisms and early human trials.
What was found
The abstract reports no quantitative data or numerical outcomes. It qualitatively describes the transition toward framing aging as a modifiable biological process and lists key molecular targets (nutrient-sensing networks including mTOR, AMPK, and sirtuins, mitochondrial regulation, proteostasis, cellular senescence) and interventions (caloric restriction, fasting-mimicking diets, rapalogues, sirtuin activators, metformin, NAD+ boosters, senolytics, GlyNAC).
Why it matters
It synthesizes the shift from historical longevity elixirs to molecular geroscience targeting biological aging to prevent multiple age-related chronic diseases.
Limits
The paper is a narrative overview without primary empirical data, systematic review methodology, or meta-analytic pooling. Most discussed interventions rely heavily on model organism data, with human evidence limited to early-stage biomarker and physiological studies.
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