The Function of Microglia in Cognitive Impairment Influenced by Sleep Deprivation.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic literature without systematic search methodology.
PubMed 41535483 · doi:10.1007/s10571-025-01654-x
What was done
A narrative review synthesizing literature from the past two decades examining the mechanisms linking sleep deprivation, microglial function, and cognitive impairment, along with potential therapeutic strategies targeting microglia.
What was found
The abstract reports no numerical findings or quantitative effect sizes. It describes proposed pathways by which microglia contribute to sleep-loss-induced cognitive decline, including excitatory neurotransmitter accumulation, Aβ plaque deposition, neuroinflammation, disrupted autophagy, abnormal cell death, and impaired synaptic plasticity.
Why it matters
It organizes the mechanistic pathways connecting sleep loss to microglial dysfunction, highlighting potential biological targets for therapeutic intervention.
Limits
As a narrative review, it lacks a systematic search methodology or meta-analytic quantification. The abstract contains no empirical data, human clinical trial metrics, or sample sizes.
Cited by
- supports Microglial cells are deeply influenced by daily lifestyle factors including nutrition, sleep, and environment.