Central Role of MITF/TFE Family Transcription Factors in Diverse Clear and Granular Cell Tumors.
Level 5 - mechanism / opinion, no new human data
Narrative review of molecular mechanisms and histopathology without primary patient data or systematic methodology.
PubMed 41655959 · doi:10.1016/j.ajpath.2026.01.010
What was done
This narrative review synthesizes literature concerning the role of the MITF/TFE transcription factor family (including TFEB and MITF) in cytoplasmic organellar biogenesis and oncogenesis across diverse benign and malignant clear cell and granular cell tumors.
What was found
The abstract reports no numerical data. It notes that MITF/TFE transcription factors regulate organellar biogenesis (TFEB for lysosomes, MITF for melanosomes) and that pathway activation contributes to the altered cell biology and distinct cytoplasmic appearances in clear and granular cell neoplasms.
Why it matters
It provides a unifying mechanistic model connecting specific transcription factor pathways and organellar biogenesis to characteristic tumor histomorphology across multiple neoplasms.
Limits
As a narrative review, it presents no primary clinical data, quantitative measurements, or systematic methodology for study inclusion.
Cited by
- supports TFEB is the master transcription factor that regulates lysosome biogenesis.