Hashimoto's thyroiditis: from pathogenesis to clinical management.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search methodology or original human data
PubMed 41704486 · doi:10.3389/fendo.2026.1729316
What was done
This paper is a narrative review synthesizing literature on the pathogenesis, epidemiology, diagnostic tools (serological testing for TPOAb/TGAb and thyroid ultrasound), and clinical management of Hashimoto's thyroiditis.
What was found
The abstract reports that Hashimoto's thyroiditis is roughly four times more common in adult women than in men and remains a major cause of hypothyroidism in iodine-sufficient regions. Standard treatment remains levothyroxine (T4) replacement. The abstract presents no original quantitative findings or effect sizes.
Why it matters
It provides a broad theoretical and clinical summary of current diagnostic and therapeutic approaches for Hashimoto's thyroiditis.
Limits
As a narrative review, it lacks systematic search criteria, quality appraisal of cited literature, and original empirical data. No specific sample sizes, effect estimates, or quantitative syntheses are reported in the abstract.
Cited by
- context Eighty to ninety percent of women diagnosed with hypothyroidism have Hashimoto's thyroiditis.