Dietary Modulation of Migraine: Metabolic, Neuroinflammatory and Microbiota-Mediated Mechanisms.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic pathways and dietary interventions without systematic review methodology.
PubMed 41753160 · doi:10.3390/jcm15041476
What was done
This narrative review synthesized literature on metabolic and mitochondrial dysfunction, gut microbiota alterations, and neuroinflammation in migraine pathophysiology. It evaluated evidence on specific dietary approaches, including ketogenic, low-carbohydrate, DASH, elimination diets, and omega-3 supplementation, as adjunctive prevention strategies.
What was found
The abstract reports no quantitative data or numerical outcomes. It qualitatively notes that specific dietary interventions may modulate metabolic and inflammatory pathways as well as gut microbiota composition, potentially reducing migraine frequency and severity.
Why it matters
The paper outlines the biological plausibility linking gut-brain interactions, energy metabolism, and diet to migraine, framing nutrition as a potential adjunctive preventive tool.
Limits
As a narrative review, it reports no new empirical data or systematic search metrics. The underlying literature is noted to be limited by small sample sizes, substantial heterogeneity, non-standardized protocols, poor adherence monitoring, and short follow-up periods.
Cited by
- context Ultra-processed foods, chemicals, and nutritional deficiencies such as magnesium deficiency contribute to the development of migraines.