Collagen supplementation and bone health - a narrative review.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic methodology or quantitative synthesis
PubMed 41962095 · doi:10.36740/WLek/218222
What was done
This narrative review summarized human studies published between 2020 and 2025 evaluating oral collagen peptide or hydrolyzed collagen supplementation on bone-related outcomes. Eligible designs included observational studies, randomized controlled trials, systematic reviews, meta-analyses, and clinical guidelines. Preclinical and animal studies were excluded.
What was found
The abstract reports no quantitative data, effect sizes, or statistical values. It qualitatively reports that oral collagen provides a beneficial supportive effect on bone health, especially in individuals with early bone loss, but cannot replace standard osteoporosis therapies due to heterogeneous evidence and limited fracture data.
Why it matters
It highlights that current evidence only supports oral collagen as an adjunctive nutritional strategy alongside standard osteoporosis regimens rather than a standalone intervention.
Limits
This is a narrative review lacking a systematic search protocol, risk of bias assessment, or quantitative pooling. The abstract omits the number of included studies, sample sizes, and dosages, and emphasizes the heterogeneity of existing literature and the lack of fracture outcome data.
Cited by
- supports A substantial portion of bone tissue is composed of collagen.