Molecular mechanisms and multi-organ regulatory roles of anti-Müllerian hormone in female reproduction.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or new human data
PubMed 42135492 · doi:10.1038/s42003-026-10273-1
What was done
This narrative review synthesizes literature on anti-Müllerian hormone (AMH) signaling mechanisms and tissue targets in female mammals. The authors evaluate downstream pathways (including Smad1/5/8, Wnt/β-catenin, and MAPK) and summarize evidence regarding AMH and AMH receptor expression across ovarian and extra-ovarian reproductive tissues.
What was found
The abstract reports no numerical findings or statistics. It describes AMH as signaling primarily through the Smad1/5/8 pathway and interacting with Wnt/β-catenin and MAPK cascades to modulate follicle growth and steroidogenesis. It also reports that AMH and its receptors are expressed in the hypothalamus, pituitary, uterus, and placenta, influencing the hypothalamic-pituitary-gonadal axis and other reproductive functions.
Why it matters
The paper frames AMH as a multi-organ signaling hub rather than solely a biomarker or local follicular inhibitor, suggesting broader regulatory roles across female mammalian reproduction.
Limits
The abstract describes a narrative review without primary human data, quantitative outcomes, or systematic literature search methodology. Details on species-specific differences, underlying study designs, and effect sizes are absent.
Cited by
- supports Anti-Müllerian hormone (AMH) is produced by the granulosa cells surrounding each ovarian follicle.