Mechanisms of NAD+ Homeostasis in Aging and Disease.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic concepts without systematic review methodology or new human trial data
PubMed 42228871 · doi:10.1146/annurev-nutr-112525-013335
What was done
The authors conducted a narrative review synthesizing current literature on how NAD+ metabolism and signaling affect cellular and organismal aging, focusing on the nutritional factors that influence NAD+ homeostasis and its relationship to age-associated diseases.
What was found
The abstract reports no quantitative metrics or numerical findings. It qualitatively summarizes that diminished NAD+ levels contribute to several hallmarks of aging and that altered NAD+ metabolism serves as a key intermediary linking impaired intercellular communication to metabolic decline in conditions including diabetes, cardiovascular disease, cancer, and neurodegenerative disorders.
Why it matters
It provides a conceptual framework linking dietary/nutritional modulation to NAD+ metabolism, metabolic resilience, and the prevention of age-related disease pathology.
Limits
The abstract contains no primary experimental or clinical data, provides no systematic search or selection criteria, presents no quantitative effect estimates, and notes that the causal direction between aging and metabolic decline remains unresolved.
Cited by
- supports NAD levels decline with aging.