Endometriosis: Epidemiology, Risk Factors, Molecular Mechanisms, Diagnosis, and Management.
Level 5 - mechanism / opinion, no new human data
Narrative review with no original data or systematic review methodology
PubMed 42428549 · doi:10.1002/mco2.70852
What was done
This narrative review summarizes literature on endometriosis, focusing on epidemiology, risk factors, and molecular mechanisms such as inflammation, epigenetic regulation, hormonal imbalance, oxidative stress, and cell invasion. It examines diagnostic modalities (laparoscopy, imaging, biomarkers) and clinical management strategies (hormonal therapy, surgery, and targeted therapies).
What was found
The abstract provides no primary data, trial outcomes, or numerical effect sizes, noting only that endometriosis affects approximately 10% of women of reproductive age globally. It describes ongoing challenges related to delayed diagnosis and suboptimal treatment, while highlighting translational pathways toward noninvasive diagnostics and targeted management.
Why it matters
It integrates current mechanistic and clinical concepts to summarize the landscape of endometriosis care and identify potential translational directions for noninvasive diagnosis and precision therapy.
Limits
As a broad narrative review, it lacks a systematic search methodology, meta-analytic data synthesis, or risk-of-bias assessment. No original empirical data are reported.
Cited by
- supports Endometriosis officially affects approximately 10% of women.
- supports Endometriosis is the leading cause of chronic pelvic pain and the leading cause of infertility in women.