Absorption kinetics of vitamins and minerals from a novel nutritional product in physically active adults: a randomized, double-blind, placebo-controlled crossover trial.
Level 2 - randomized trial
Randomized double-blind placebo-controlled crossover clinical trial
PubMed 42518997 · doi:10.3389/fnut.2026.1793264
What was done
Sixteen healthy, physically active adults (8 males, 8 females) participated in a randomized, double-blind, placebo-controlled crossover trial. After a 10-hour overnight fast, subjects consumed a single 13 g serving of AG1 or a taste- and appearance-matched placebo in water, separated by a 1-week washout period. Blood was drawn at 0, 30, 60, 90, 120, 180, 240, 360, and 480 minutes post-ingestion to assess pharmacokinetic parameters (AUC 0-480 min, Cmax, Tmax) of folate, calcium, zinc, vitamin C, biotin, nicotinamide, pyridoxine, riboflavin, thiamine, and hesperidin.
What was found
AG1 significantly increased AUC 0-480 min (p < 0.05) for folate, calcium, zinc, vitamin C, biotin, nicotinamide, riboflavin, thiamine, and hesperidin compared with placebo. Pyridoxine did not show a statistically significant increase (p = 0.1205). Exact pharmacokinetic numbers (concentrations, Cmax, Tmax) were not reported in the abstract. No serious adverse events occurred.
Why it matters
Nutrient interactions in complex multi-ingredient supplements may alter bioavailability; this trial provides pharmacokinetic evidence that most tested micronutrients and phytochemicals in the formulation are effectively absorbed acutely.
Limits
The sample size is very small (n = 16) and limited to healthy, physically active adults. Only acute single-dose pharmacokinetics over 8 hours were measured, not long-term tissue status or functional health outcomes. Absolute numerical pharmacokinetic values were omitted from the abstract.
Cited by
- supports One scoop of AG1 contains 75 vitamins, minerals, probiotics, and whole-food sourced ingredients.
- partial Clinical trials on AG1 NextGen demonstrated that it fills common nutrient gaps and improves key nutrient levels within 3 months.
- supports AG1 NextGen is backed by four clinical trials.
- context Four clinical trials show that AG1 Next Gen fills common nutrient gaps, improves key nutrient levels within three months, and increases healthy gut bacteria by 10 times, even in people who eat well.