Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials.
Level 1 - systematic review of randomized trials
Systematic review of randomized controlled trials
PubMed 42572627 · doi:10.7759/cureus.112403
What was done
Authors systematically reviewed PubMed, Embase, and CENTRAL through January 2026 for randomized clinical trials evaluating polynucleotides (PN) and polydeoxyribonucleotides (PDRN) in skin rejuvenation, postoperative scar prevention, and wound healing. Seven randomized trials totaling 183 participants were included: four on skin rejuvenation, one on scar prevention, and two on wound healing.
What was found
PN and PDRN therapies were reported to improve wrinkle-related metrics, scar quality, wound-healing parameters (specifically accelerated re-epithelialization and shortened healing time relative to controls), and patient-reported satisfaction. No serious treatment-related adverse events were documented. The abstract reports no numerical outcome values, effect sizes, or confidence intervals.
Why it matters
This review compiles the limited randomized evidence for injectable DNA-derived therapies across aesthetic and regenerative dermatology, finding the most consistent clinical signal in wound healing.
Limits
The total evidence base is extremely small (183 participants spread across seven trials and three separate indications). The abstract explicitly notes substantial treatment protocol heterogeneity and variable outcome measures, and provides no meta-analytic pooling.
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